Templated xerogels as platforms for biomolecule-less biomolecule sensors.

Sesterin as a biomolecule

Sestrins (Sesns), highly conserved stress-inducing metabolic proteins, are known to protect organisms against various harmful stimuli including DNA damage, oxidative stress, endoplasmic reticulum (ER) stress, and hypoxia. Sestrins regulate metabolism mainly through activation of AMP-dependent protein kinase (AMPK) and inhibition of rapamycin complex 1 (mTORC1). Sestrins also play a pivotal role...

Polymerization Control of Templated Recognitive Structures

This work highlights the rational design of recognitive networks via polymerization reaction analysis and detailed kinetic analysis for application in novel diagnostic or robust point-of-care devices. Non-covalent complexation interactions between template or ‘guest' biomolecules and functional monomers during polymerization can create networks with selective binding sites for biomolecules with...

Cyclewise Operation of Printed MoS2 Transistor Biosensors for Rapid Biomolecule Quantification at Femtomolar Levels.

Field-effect transistors made from MoS2 and other emerging layered semiconductors have been demonstrated to be able to serve as ultrasensitive biosensors. However, such nanoelectronic sensors still suffer seriously from a series of challenges associated with the poor compatibility between electronic structures and liquid analytes. These challenges hinder the practical biosensing applications th...

Biomolecule size-dependent sensitivity of porous silicon sensors

Biomolecule-responsive Behavior of Smart Gels Having Biomolecular Complexes as Reversible Cross-links

Introduction Stimuli-responsive gels undergo abrupt changes in volume in response to environmental changes such as pH and temperature. Stimuli-responsive gels have attracted considerable attention as smart materials in the biochemical and biomedical fields, since they can sense environmental changes and induce structural changes by themselves. The fascinating properties of such stimuli-responsi...